Yes – you won't get things like server push but the core feature of allowing the browser to queue a large number of requests and receive responses out of order is a big win even if you do nothing else.
chadaustin already mentioned nginx, which seems to be the most popular choice.
… and Apache Traffic Server just shipped support in v5.3.0, which might be of interest if you want to setup a generic front-end layer for a ton of backend services:
One thing I haven't looked into is whether any of these will try to use server push for content which has is referenced by <link rel=preload> in an HTML page. That could be very useful for render-blocking CSS/JS.