Sure you can, but the technology of the future is not being built or run on windows stacks. You find it everywhere in the enterprise, yet almost every big new tech company that has come up in the last 10 years all rely primarily on open source technology.

Xamarin / Mono and Unity run pretty much everywhere. Unity even runs on WebGL, none of this is tied to windows stacks.

Also, Microsoft has a great startup programme with Bizspark, we built a company on it a few years ago that eventually ended up as part of a $700m acquisition

And ASP.NET will now run everywhere too (that's one major chunk of this vNext stuff).

Of course, I was focusing on the current ecosystem. I'm very excited for the future of ASP.NET and C#