For those people who like to read instead of watch:
Bateria
o oldest living things
o very few genes
o consume nutients
o grow and divide themselves
o good and bad Bacteria
o Considered before as "a-social reclusive organisms"
Human
o Trillian Human cells
o 10 Trillion Baterial cells
o DNA counts, 100 times more Baterial life than you are Human
o Bateria cover us outside, they make our vitamins, etc. They are vital for us.
Case Study: Vibrio Fischeri (3:00)
o makes biolumencense
o they make only light in a special situation
o alone no light,
o secretes small "hormon" type substances to communicate
o after a certain level of "hormon" type substance is gathered they "turn on"
o Bacterial Quorum Sensing
- They have a Signal Producing Protein)
- They have also a Signal Receptor Protein
- Locks on Proteins then Group Behaior Genes are
activiated
Case Study: Squid (5:00)
o squid uses those Bacteria in symbiosis
o buries itself in sand during day
o senses moonlight with a special eye like organ on the back
o analogy "stealth bomber of the ocean"
o only active during night
o pumps up bacteria if needed to make light
Quorum Sensing in Bacteria (9:10)
o All bacteria can actually talk to each other.
o Bacteria are multi-cellular
o Bacteria can distinguish self from other
o Quorum Sensing, every bacteria can "vote"
- "counting your neighbors"
o the most votes get carried out
o Bacterial control patogens with Quorum Sensing.
- growing while doing nothing, then when enough numbers
attack
o Bacteria can develop strategies to impede/improve
quiorum sensing
o Display of different molecules
- left hand part of the molecule is same only right part is slightly different
- each bacteria uses a special right hand side version of vibrio fischeri
- In-trust species communication by unique molecule types
o Bacteria are multi-lingual. They can also communicate Inter-Species. (11:40)
- There is a bacteria molecule which is always the same
o Chemicals are their "word"
New Anti-Biotics (12:30)
o Can we disturb communication of them so that they can't release pathogens?
o Two strategies
- disturbing -> targeting intra-species communication (works, mouse)
- disturbing -> targeting inter-species comm.
o This will be the next generation of Anti-Biotics
Future work (15:30)
o Study bacterials because they have been longer around then us
o Application to other Human diseses and behaviors
o Anti- but also Pro- Quorum Sensing bacteria
- Making you more healthy
o Her team (17:20)
Bateria
Human Case Study: Vibrio Fischeri (3:00) activiatedCase Study: Squid (5:00)
Quorum Sensing in Bacteria (9:10) attack quiorum sensing New Anti-Biotics (12:30) Future work (15:30)