I remember there's a PCI device that's meant to be snooping and manipulating RAM directly by using DMA. Pretty much one computer runs the game and one computer runs the cheat. I think kernel anti cheats are just raising the bar while pretty much being too intrusive
Technically yes, but it would produce an untrusted remote attestation signature (quote). This is roughly equivalent to using TLS with a self-signed certificate — it’s not trusted by anyone else. TPMs have a signing key that’s endorsed by the TPM vendor’s CA.