+1

And if not, could you elaborate?

It would also be a huge benefit to use a replaced mainboard as a homelab base WITH ECC support in the future.

Same goes for the Framework Desktop, which features Strix Halo without ECC support, whereas ECC IS possible with Ryzen AI MAX+ 395+ PRO (e.g. HP Z2 Mini G1a).

Can't speak for Framework, but AMD themselves doesn't necessarily support this configuration so it would be on Framework to develop/test/certify a compatibility list... they'd likely only support first party modules, if anything. At least for non-pro AMD CPUs.

Likely mostly down to resources/time as to the lack of official support.

Yes, we often hear it is "not supported." I'm here saying all my future non-mobile devices are required have ECC RAM or better. Take the money. ;-)