| 1. | | How to deal with receiving a cease-and-desist letter from Big Tech (12challenges.substack.com) |
| 544 points by louisbarclay on Jan 30, 2024 | 202 comments |
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| 2. | | The Smol Training Playbook: The Secrets to Building World-Class LLMs (huggingface.co) |
| 265 points by kashifr 5 months ago | 19 comments |
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| 3. | | How to build a coding agent (ghuntley.com) |
| 472 points by ghuntley 7 months ago | 122 comments |
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| 4. | | Dispelling misconceptions about RLHF (aerial-toothpaste-34a.notion.site) |
| 120 points by fpgaminer 8 months ago | 32 comments |
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| 5. | | Do things that don't scale, and then don't scale (derwiki.medium.com) |
| 516 points by derwiki 8 months ago | 207 comments |
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| 6. | | [flagged] The Gutting of America's Medical Research (nytimes.com) |
| 91 points by pmags 10 months ago | 88 comments |
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| 7. | | AI in my plasma physics research didn’t go the way I expected (understandingai.org) |
| 366 points by qianli_cs 11 months ago | 299 comments |
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| 8. | | Baby is healed with first personalized gene-editing treatment (nytimes.com) |
| 1257 points by jbredeche 11 months ago | 531 comments |
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| 9. | | Will protein design tools solve the snake antivenom shortage? (owlposting.com) |
| 63 points by sebg 11 months ago | 28 comments |
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| 10. | | How are cyber criminals rolling in 2025? (vin01.github.io) |
| 266 points by vin10 11 months ago | 92 comments |
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| 11. | | China's Clinical Trial Boom (asimov.press) |
| 160 points by surprisetalk 11 months ago | 107 comments |
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| 12. | | The Molecule of the Month (bris.ac.uk) |
| 35 points by fhlu on March 19, 2025 | 7 comments |
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| 13. | | What's happening inside the NIH and NSF (science.org) |
| 957 points by rrock on Feb 4, 2025 | 1536 comments |
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| 14. | | The Illustrated Guide to a PhD (might.net) |
| 410 points by chii on Jan 12, 2025 | 246 comments |
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| 15. | | Ask HN: Books about people who did hard things |
| 495 points by zachlatta on Jan 6, 2025 | 437 comments |
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| 16. | | Ask HN: A friend has brain cancer: any bio hacks that worked? |
| 157 points by d--b on Jan 9, 2025 | 364 comments |
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| 17. | | In my life, I've witnessed three elite salespeople at work (slate.com) |
| 504 points by mooreds on Jan 5, 2025 | 287 comments |
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| 18. | | I made $100K from a dick joke (imgur.com) |
| 532 points by imglorp on Jan 5, 2025 | 260 comments |
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| 19. | | Developing a cancer drug without Big Pharma: this hospital shows it can be done (ftm.nl) |
| 197 points by yread on Nov 27, 2024 | 154 comments |
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| 20. | | Antibody Drug Conjugates: A frontier in cancer treatment (sagelyhealth.com) |
| 107 points by peerless-app on Oct 31, 2024 | 44 comments |
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| 21. | | Ask HN: Founders, what was the major sourcing channel for your first 100 users? |
| 282 points by jainvivek on Oct 16, 2024 | 191 comments |
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| 22. | | Reflections on Palantir (nabeelqu.substack.com) |
| 482 points by freditup on Oct 16, 2024 | 581 comments |
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| 23. | | On the Nature of Time (stephenwolfram.com) |
| 361 points by iamwil on Oct 8, 2024 | 261 comments |
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| 24. | | Fuzzing 101 (github.com/antonio-morales) |
| 280 points by udev4096 on Oct 5, 2024 | 17 comments |
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| 25. | | If AI seems smarter, it's thanks to smarter human trainers (reuters.com) |
| 182 points by getwiththeprog on Sept 28, 2024 | 132 comments |
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| 26. | | Forbes Marketplace: The Parasite SEO Company Trying to Devour Its Host (larslofgren.com) |
| 646 points by greg_V on Sept 19, 2024 | 299 comments |
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| 27. | | How to succeed in MrBeast production (Leaked PDF) (simonwillison.net) |
| 2115 points by babelfish on Sept 15, 2024 | 1352 comments |
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| 28. | | 'Right to Repair for Your Body': The Rise of DIY, Pirated Medicine (404media.co) |
| 34 points by Osiris30 on Sept 7, 2024 | 4 comments |
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| 29. | | Getting price-gouged by private equity in the UK's happiest resort (2023) (netincome.co) |
| 93 points by jjar on Sept 3, 2024 | 120 comments |
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| 30. | | Drug Development Failure: how GLP-1 development was abandoned in 1990 (jhu.edu) |
| 152 points by bookofjoe on Aug 30, 2024 | 166 comments |
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| More |
